From the rough text notes from Niel Short’s sermon:
We should notice a few important features of this text. First off, God did not expect the creation to turn out this way. In fact, God is ready to wipe out something about which he had earlier said was “very good.” God is reacting to human actions (Isaiah 9:11-12; Malachi 3:6;Jeremiah 18). God changed his mind. God has always reserved the right to change his mind (Exodus 32:14; Psalm 106:23; 1 Samuel 2:30; Jeremiah 15:6)
God experiences emotion. God is sorry/regrets/repents(KJV) (1 Samuel 15:11). God’s experience at the beginning of verse 6 (sorrow) connotes a definite change. When God experienced this sorrow, he was not experiencing it before he “saw that the wickedness of humankind was great on the earth.” After God saw what he saw, he changed. He was sorry. Thus, very appropriately, the KJV gives the word “repented.”
God grieves. “It grieved him to his heart.” Grief is emotional suffering in proportion to intimacy. The Bible is replete with examples of God’s grief.
Psalm 78:40; Isaiah 63:10; Luke 19:41-42; John 11:33-35; Ephesians 4:30. In Hosea 11:8-9, God is torn in heart.